The stress response is superb engineering for its actual purpose: a short-term emergency. Cortisol and adrenaline mobilize glucose, sharpen attention, raise heart rate, and postpone everything non-urgent — digestion, growth, reproduction, immune maintenance — because a zebra being chased by a lion has no business digesting lunch. The system is designed to switch on hard and then switch off.
The damage comes from the switch never flipping back. Humans can activate a stress response with a thought — a looming deadline, a difficult relationship, a bad news cycle — and sustain it for months. Chronically elevated stress hormones suppress immune function, impair memory formation in the hippocampus, worsen cardiovascular risk, and disrupt sleep, which then feeds back into more stress. The intervention isn't eliminating stress, which is neither possible nor desirable — it's ensuring recovery: real off-periods where the system stands down.
The Stanford neurobiologist Robert Sapolsky spent over three decades studying a troop of wild baboons in Kenya, darting them to measure stress hormones and correlating the results with their social rank and behavior. Baboons are a useful model precisely because, like humans, they don't face many real predators — their stressors are social. Sapolsky found that low-ranking baboons, who endured chronic social subordination, had persistently elevated cortisol, higher blood pressure, more atherosclerotic plaque, and suppressed immune function. But rank wasn't the whole story: the healthiest baboons at any rank were those with strong social bonds and effective coping behavior. His book's title captures the thesis — a zebra fleeing a lion mounts a massive stress response for three minutes and then goes back to grazing. It doesn't get ulcers. Humans, and socially stressed baboons, keep the response running for years.